Xianfeng Lin

Cellular energy metabolic disorders are fundamental and widespread causes of bone injuries and degenerative diseases. However, our understanding of the energy metabolism and regulatory mechanisms in these cells remains limited.

Xianfeng Lin focuses on the energy metabolism and regulatory mechanisms of cells during the processes of damage, degeneration, and death in musculoskeletal diseases. His goal is to alter disease progression through energy delivery, thereby enabling precise treatment for specific diseases.

Drawing inspiration from the story of Popeye the Sailor, he led his team to discover that ATP and NADPH, serving as the “energy currency” and “material currency” throughout the evolutionary history of living organisms, are universally applicable across species. He successfully transplanted the photosynthetic system of plants into degenerative mammalian cells, creating a novel, dynamic, and real-time “energy factory” within mammalian cells. This approach overcomes the inefficiency and side effects associated with traditional energy delivery methods. It is expected to be extended to the treatment of critical organ diseases such as myocardial infarction, cerebral infarction, and Alzheimer’s disease.